Currently Recruiting Clinical Trials

Healthy Volunteers are required for a clinical trial to compare investigational Influenza and combined COVID-19 and Influenza vaccines against separate COVID-19 and Influenza vaccines.

You may be eligible to take part if you:

• Are aged 65 years or older
• Are in general good health
• Have received at least 2 COVID-19 vaccines
• Have not had an Influenza or COVID-19 vaccine within 8 weeks prior to study vaccination
• Have not received any other vaccines within 4 weeks prior to study vaccination
• Are able and willing to comply with trial requirements (e.g. e-diary completion, blood tests, trial site visits)

Trial participation will include the administration of either the study combined vaccine OR flu study vaccine OR influenza comparator vaccine OR an experimental comparator Novavax COVID-19 vaccine. These will be assigned randomly.

Study participation will last approximately 12 months for each participant and will include 8 scheduled visits.

If you are interested in finding out more, please contact the study coordinator on 03 4215 2880 or alicia.waight1@barwonhealth.org.au

This trial has been approved by an independent ethics committee.

The Flash Study is a national randomised controlled clinical trial for Indigenous Australians with type 2 diabetes using Flash glucose monitors compared to standard care (finger-pricks).

The study will involve attending 6 visits over 6 months. To learn more about the study, please click here to watch a 3 minute video.

You may be eligible to take part in the study if you:

• are an Indigenous Australian
• have a confirmed diagnosis of type 2 diabetes
• are at least 18 years of age

To check your eligibility or see if this trial is right for you please call or email the study team on alicia.waight1@barwonhealth.org.au or 03 4215 2880.

Are you planning to have a laparoscopy (keyhole surgery) for pelvic pain? You may be eligible for our study!

What is involved? You will be asked to:

• Complete an online questionnaire before your surgery
• Attend a consultation with a physiotherapist before your surgery for an assessment of your pelvic floor muscle
• Complete follow up online questionnaires and physiotherapy visits at 3 months and 12 months after surgery.

You will be given a $20 retail voucher for your travel expenses to each physiotherapy visit. On your last visit, you will also be given the device used to assess your pelvic floor muscles, called a ‘Femfit’, to keep for your future use!

Interested?

If you would like to find out more or be involved, please click here or contact the study team directly at: Endo-Research@unimelb.edu.au

How is an older person’s age considered when doctors and older people make decisions about health and wellbeing? We are interested in your experiences and views.

Who can participate?

Doctors or older people (age over 65 or over 50 if an Aboriginal or Torres Strait Islander person) who live within one hour of Geelong. 

What is involved?

A 20-30 minute face to face interview at a location of your choosing

For further information contact Dr Lisa Mitchell via email lisamit@barwonhealth.org.au.

Barwon Health Ethics Approval Project ID: 23/173

The ARC Trial is a clinical trial that will compare arthroscopic shoulder surgery where the rotator cuff tear is repaired, to the same surgery without repairing the rotator cuff. This research project is testing whether surgery to repair the tear is an effective treatment to improve shoulder pain and function and quality of life in people with rotator cuff tears.

You may be eligible to take part in the trial if you:

• Are aged between 45-75 years old
• Have been suffering from shoulder problems for the last six months
• Have been diagnosed as having a reparable rotator cuff tear, which was confirmed by an MRI imaging scan

To find out more, please contact Dr Kirsten Porter, Orthopaedic Research Coordinator, on (03) 4215 2208 or kirsten.porter@barwonhealth.org.au

This study has ethical approval from UNSW Human Research Ethics Committee

Recruitment is starting soon for the RAPSODI-AUS study, which compares two common types of shoulder replacement: the Total Shoulder (Anatomic) replacement, and the Reverse Shoulder replacement. These are the two types of shoulder replacement that surgeons use very often for patients with osteoarthritis who need a shoulder replacement. They both help to reduce pain and maintain or improve movement, and the aim of this study is to explore which method works best.

You may be eligible to take part in the trial if you:

• Are aged 60 years and over
• Have been diagnosed as having shoulder osteoarthritis
• An intact rotator cuff (determined via pre-operative advanced imaging)

To find out more, please contact Dr Kirsten Porter, Orthopaedic Research Coordinator, on (03) 4215 2208 or kirsten.porter@barwonhealth.org.au

This study has ethical approval from Metro North Health Human Research Ethics Committee

What is the HARMON-E study?

The HARMON-E trial is a group-based, telehealth clinical trial designed to support positive lifestyle changes to improve mental health for adults who are experiencing depression or bipolar disorder. HARMON-E is based on well-established evidence for lifestyle interventions as effective strategies for improving depressive symptoms and common associated physical health conditions. 

How are we doing this study?

We are recruiting 378 people (18+) from across Australia to participate in this study. Participants are randomly allocated into one of two programs: 1) led by allied health professionals and 2) led by clinical psychologists. Each program is 8 weeks long and we will measure changes in depressive symptoms over this period and compare them between the two groups.

Participants are asked to: 

• Join one 30-minute one-on-one introductory session with their interventionist via video call (Zoom)
• Join six 90-minute mental health therapy sessions via video call with a group of up to 7 other people (the same group each time)
• Answer questions in 5 one-on-one interviews over zoom about your health and wellbeing
• Make 2 visits to your local pathology to have a blood test and your height and weight measured
• Collect 2 stool samples at home

What are we hoping to find? 
The trial aims to determine whether a lifestyle-based approach to mental health care is as good as psychotherapy for reducing symptoms of depression.

Interested in participating?

If you are interested in participating you can complete a quick, 5 minute online pre-screening survey to see if you may be eligible.
The survey can be found here: HARMON-E Trial prescreening survey (deakin.edu.au)

You can contact the HARMON-E Team at harmone@deakin.edu.au or 03 5227 2380
Food & Mood Centre,IMPACT Institute, Deakin University,  www.foodandmoodcentre.com.au

We are currently seeking participants for a study investigating the negative symptoms of schizophrenia

The study will be conducted at the Adrian Costa Clinical Trials Centre in Geelong and consists of a single appointment that includes:

• An interview to discuss your mental health.
• Taking of your blood for later testing.
• Cognitive tasks to assess your memory, attention, and processing speed.
• Measurement of weight, height, and blood pressure.

Inclusion criteria:

• Age 18+ years
• A clinical diagnosis of a psychotic disorder such as schizophrenia, schizophreniform psychosis, schizoaffective disorder, or related disorder.

If you are interested in participating, please email bionecs_study@deakin.edu.au or call Research Assistant Marko Milicevic at (03) 5227 2229 for more information.

We are also seeking referrals from clinicians who treat psychotic disorders in the Barwon region.

This study has ethical approval from Barwon Health Human Research Ethics Committee, HREC/79204/VICBH-2022-331357(v3).

To view the cancer trials currently underway at Barwon Health, visit the Victorian Cancer Trials Link website.

Searching this website is easy. All you have to do is type information about you, your cancer or cancer treatment to begin. Once you have begun the search, you can narrow your results by selecting criteria on the left hand side of the page.

Once you have found a trial that you think you can join, speak to your doctor or contact the Barwon Health Cancer Services Trials Unit for more information.

Barwon Health is currently looking for participants for a clinical trial to prevent Urinary tract infections (UTIs)

Participants would be required to attend several visits over a 3 year period.

You may be eligible if you are:

• Adults aged ≥ 60 years
• Have a history of UTI in the past 2 years
• In generally good health

For more information please call 03 4215 2877 or email Fahriya.Zandari@barwonhealth.org.au

This study has been approved by Monash Human Research Ethics Committee

If you are interested in finding out more about participating in any of our current trials, please contact us at (03) 4215 1033 or cardiologyresearch@barwonhealth.org.au

Poseidon:

Ongoing chronic and systemic inflammation is an important contributor to the risk of recurrent cardiovascular events in patients with established diagnoses of atherosclerotic cardiovascular disease (ASCVD) and/or heart failure (HF). ASCVD and HF are highly comorbid conditions, which are also commonly co-morbid with chronic kidney disease (CKD).

In this research study we will be looking into

• how often people with cardiovascular disease have high levels of inflammation
• if there are common characteristics of patients with high levels of inflammation.

This study will also test the participants for possible risk of kidney or liver disease. This is to see if participants with these co-occurring diseases are more likely to have high levels of inflammation.

You may be eligible if:

• Are 18 + years of age
• Have been diagnosed with blockages in your arteries– legs, heart or neck. Or if you have been diagnosed with heart failure with or without kidney disease

 

BALANCED HF:

We are doing this study to learn about how effective, safe and tolerable an experimental drug called balcinrenone is when used in combination with dapagliflozin for treating patients with heart failure and impaired kidney function. This research also aims to better understand your condition and associated health problems.

• Are 18 + years of age
• Diagnosed heart failure
• Have had a recent admission to hospital due to your heart failure or an urgent outpatient visit with your cardiologist in the past 6 months

 

ACCLAIM Study:

Lp(a) carries cholesterol (a type of fat) in the blood. Elevated levels of Lp(a) can put you at a higher risk of heart disease, stroke, or peripheral artery disease. This research project is testing a potential new treatment for its ability to lower the levels of Lp(a) and hence reduce the risk of major bad effects related to heart disease (for example, heart attack, stroke, or death).

 You are potentially eligible to participate in the study if you fit the following criteria:

• 18 years of age or older with history of heart disease
• or 55 years of age or older who are at risk for the first heart disease

 

HERMES Study:

This study will assess the efficacy and safety of ziltivekimab for the treatment of people living with heart failure and inflammation. The study also aims to better understand heart failure and related diseases and how to improve treatment for these conditions.

You may be eligible to take part if you:

• Are 18 + years of age
• Have been diagnosed with heart failure and reduced kidney function

 

EASY AS Study:

Your heart valve condition (aortic stenosis, or AS) is a common condition in which one of the four heart valves narrows over many years. When a valve becomes narrow, it can reduce the flow of blood through the heart and the body. Symptoms can include shortness of breath and chest pain; these can take years to develop and some patients never develop symptoms at all.

Patients who do have symptoms can have the valve replaced. This works really well, but as with any medical procedure, there is a chance of complications, and it can take a long time to recover. Some heart specialists believe that replacing the valve before symptoms develop may be better than the more conventional approach of performing the AVR once symptoms develop.

You may be eligible to take part if you:

• Are 18 + years of age
• Have a diagnosis of severe aortic stenosis but no symptoms

 

ARTEMIS Study:

People who experience a heart attack are, even with the best medicines and care, at risk of suffering from a new heart attack or stroke (blocked blood supply to the brain). This is due to a continuous build-up of fat in their blood vessels, so-called plaque, which is driven by a process known as ‘inflammation’.

After a heart attack, inflammation is often increased. Ziltivekimab is an antibody that is taken once a month by injection. Antibodies are proteins that target and neutralise unwanted objects in the body. Ziltivekimab targets inflammation; specifically, the inflammation that leads to the build-up of fat in the blood vessels. In that way, ziltivekimab can help the body to avoid more inflammation, which may reduce development of heart disease and stroke.

You may be eligible to take part if you:

• Are 18+ years of age
• Are admitted in hospital for a heart attack

 

TRIUMPH OUTCOMES Study: 

The primary purpose of this research project is to learn more about retatrutide (LY3437943) as a treatment for participants with a body mass index (BMI) exceeding 27 kg/m² and suffering from heart-related and/or kidney-related diseases.

The research project help answer the following research question(s):

• Whether retatrutide can work better than a placebo in
  • reducing the risk of major heart related events and
  • reducing the decline in kidney function.
• What are the possible side effects of retatrutide.

You may be eligible to take part if you:

• Are 18+ years of age
• Have a BMI of/more than 27 kg/m2
• Have cardiovascular disease +/- kidney disease